Conditional control of universal CAR T cells by cleavable OFF-switch adaptors

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As living drugs, engineered T cell therapies are revolutionizing disease treatment with their unique functional capabilities. However, they suffer from limitations of potentially unpredictable behavior, toxicities, and non-traditional pharmacokinetics. Engineering conditional control mechanisms resp...

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Detalles Bibliográficos
Autores principales: Kvorjak, Michael, Ruffo, Elisa, Tivon, Yaniv, So, Victor, Parikh, Avani B., Deiters, Alexander, Lohmueller, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245878/
https://www.ncbi.nlm.nih.gov/pubmed/37292935
http://dx.doi.org/10.1101/2023.05.22.541664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245878/
https://www.ncbi.nlm.nih.gov/pubmed/37292935
http://dx.doi.org/10.1101/2023.05.22.541664

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