Electrostatically regulated active site assembly governs reactivity in non-heme iron halogenases

Non-heme iron halogenases (NHFe-Hals) catalyze the direct insertion of a chloride/bromide ion at an unactivated carbon position using a high-valent haloferryl intermediate. Despite more than a decade of structural and mechanistic characterization, how NHFe-Hals preferentially bind specific anions an...

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Detalles Bibliográficos
Autores principales: Smithwick, Elizabeth R., Wilson, R. Hunter, Chatterjee, Sourav, Pu, Yu, Dalluge, Joseph J., Damodaran, Anoop Rama, Bhagi-Damodaran, Ambika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245910/
https://www.ncbi.nlm.nih.gov/pubmed/37292651
http://dx.doi.org/10.1101/2023.05.25.542349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245910/
https://www.ncbi.nlm.nih.gov/pubmed/37292651
http://dx.doi.org/10.1101/2023.05.25.542349

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