Mast cell-derived BH4 is a critical mediator of postoperative pain

Postoperative pain affects most patients after major surgery and can transition to chronic pain. Here, we discovered that postoperative pain hypersensitivity correlated with markedly increased local levels of the metabolite BH4. Gene transcription and reporter mouse analyses after skin injury identi...

Descripción completa

Detalles Bibliográficos
Autores principales: Starkl, Philipp, Jonsson, Gustav, Artner, Tyler, Turnes, Bruna Lenfers, Serhan, Nadine, Oliveira, Tiago, Gail, Laura-Marie, Stejskal, Karel, Channon, Keith M., Köcher, Thomas, Stary, Georg, Klang, Victoria, Gaudenzio, Nicolas, Knapp, Sylvia, Woolf, Clifford J., Penninger, Josef M., Cronin, Shane J.F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245978/
https://www.ncbi.nlm.nih.gov/pubmed/37293068
http://dx.doi.org/10.1101/2023.01.24.525378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245978/
https://www.ncbi.nlm.nih.gov/pubmed/37293068
http://dx.doi.org/10.1101/2023.01.24.525378

Ejemplares similares