Single-cell RNA sequencing data reveals rewiring of transcriptional relationships in Alzheimer’s Disease associated with risk variants

Understanding how genetic risk variants contribute to Alzheimer’s Disease etiology remains a challenge. Single-cell RNA sequencing (scRNAseq) allows for the investigation of cell type specific effects of genomic risk loci on gene expression. Using seven scRNAseq datasets totalling >1.3 million ce...

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Detalles Bibliográficos
Autores principales: Bouland, Gerard A., Marinus, Kevin I., van Kesteren, Ronald E., Smit, August B., Mahfouz, Ahmed, Reinders, Marcel J.T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246028/
https://www.ncbi.nlm.nih.gov/pubmed/37292975
http://dx.doi.org/10.1101/2023.05.15.23289992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246028/
https://www.ncbi.nlm.nih.gov/pubmed/37292975
http://dx.doi.org/10.1101/2023.05.15.23289992

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