Lifetime of ground conformational state determines the activity of structured RNA

Biomolecules continually sample alternative conformations. Consequently, even the most energetically favored ground conformational state has a finite lifetime. Here, we show that, in addition to the 3D structure, the lifetime of a ground conformational state determines its biological activity. Using...

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Detalles Bibliográficos
Autores principales: Thompson, Rhese D., Carbaugh, Derek L., Nielsen, Joshua R., Witt, Ciara M., Meganck, Rita M., Rangadurai, Atul, Zhao, Bo, Bonin, Jeffrey P., Nicely, Nathan I., Marzluff, William F., Frank, Aaron T., Lazear, Helen M., Zhang, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246243/
https://www.ncbi.nlm.nih.gov/pubmed/37292668
http://dx.doi.org/10.21203/rs.3.rs-2879957/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246243/
https://www.ncbi.nlm.nih.gov/pubmed/37292668
http://dx.doi.org/10.21203/rs.3.rs-2879957/v1

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