Synthesis of sp(3)-rich heterocyclic frameworks by a divergent synthesis strategy

Fragment-based lead discovery (FBLD) often relies on flat, aromatic compounds which display undesirable physicochemical properties with limited exit vectors for fragment growth. Herein, we report concise synthetic strategies to sp(3)-rich heterocyclic fragments encompassing polar exit vectors poised...

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Detalles Bibliográficos
Autores principales: Mortensen, Kim T., Wong, Denedy S. Y., King, Thomas A., Sore, Hannah F., Spring, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246434/
https://www.ncbi.nlm.nih.gov/pubmed/37203457
http://dx.doi.org/10.1039/d3ob00351e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246434/
https://www.ncbi.nlm.nih.gov/pubmed/37203457
http://dx.doi.org/10.1039/d3ob00351e

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