Synthesis of sp(3)-rich heterocyclic frameworks by a divergent synthesis strategy

Fragment-based lead discovery (FBLD) often relies on flat, aromatic compounds which display undesirable physicochemical properties with limited exit vectors for fragment growth. Herein, we report concise synthetic strategies to sp(3)-rich heterocyclic fragments encompassing polar exit vectors poised...

Descripción completa

Detalles Bibliográficos
Autores principales: Mortensen, Kim T., Wong, Denedy S. Y., King, Thomas A., Sore, Hannah F., Spring, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246434/
https://www.ncbi.nlm.nih.gov/pubmed/37203457
http://dx.doi.org/10.1039/d3ob00351e
_version_ 1785055030857957376
author Mortensen, Kim T.
Wong, Denedy S. Y.
King, Thomas A.
Sore, Hannah F.
Spring, David R.
author_facet Mortensen, Kim T.
Wong, Denedy S. Y.
King, Thomas A.
Sore, Hannah F.
Spring, David R.
author_sort Mortensen, Kim T.
collection PubMed
description Fragment-based lead discovery (FBLD) often relies on flat, aromatic compounds which display undesirable physicochemical properties with limited exit vectors for fragment growth. Herein, we report concise synthetic strategies to sp(3)-rich heterocyclic fragments encompassing polar exit vectors poised for fragment-to-lead (F2L) development.
format Online
Article
Text
id pubmed-10246434
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-102464342023-06-08 Synthesis of sp(3)-rich heterocyclic frameworks by a divergent synthesis strategy Mortensen, Kim T. Wong, Denedy S. Y. King, Thomas A. Sore, Hannah F. Spring, David R. Org Biomol Chem Chemistry Fragment-based lead discovery (FBLD) often relies on flat, aromatic compounds which display undesirable physicochemical properties with limited exit vectors for fragment growth. Herein, we report concise synthetic strategies to sp(3)-rich heterocyclic fragments encompassing polar exit vectors poised for fragment-to-lead (F2L) development. The Royal Society of Chemistry 2023-05-16 /pmc/articles/PMC10246434/ /pubmed/37203457 http://dx.doi.org/10.1039/d3ob00351e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Mortensen, Kim T.
Wong, Denedy S. Y.
King, Thomas A.
Sore, Hannah F.
Spring, David R.
Synthesis of sp(3)-rich heterocyclic frameworks by a divergent synthesis strategy
title Synthesis of sp(3)-rich heterocyclic frameworks by a divergent synthesis strategy
title_full Synthesis of sp(3)-rich heterocyclic frameworks by a divergent synthesis strategy
title_fullStr Synthesis of sp(3)-rich heterocyclic frameworks by a divergent synthesis strategy
title_full_unstemmed Synthesis of sp(3)-rich heterocyclic frameworks by a divergent synthesis strategy
title_short Synthesis of sp(3)-rich heterocyclic frameworks by a divergent synthesis strategy
title_sort synthesis of sp(3)-rich heterocyclic frameworks by a divergent synthesis strategy
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246434/
https://www.ncbi.nlm.nih.gov/pubmed/37203457
http://dx.doi.org/10.1039/d3ob00351e
work_keys_str_mv AT mortensenkimt synthesisofsp3richheterocyclicframeworksbyadivergentsynthesisstrategy
AT wongdenedysy synthesisofsp3richheterocyclicframeworksbyadivergentsynthesisstrategy
AT kingthomasa synthesisofsp3richheterocyclicframeworksbyadivergentsynthesisstrategy
AT sorehannahf synthesisofsp3richheterocyclicframeworksbyadivergentsynthesisstrategy
AT springdavidr synthesisofsp3richheterocyclicframeworksbyadivergentsynthesisstrategy

Ejemplares similares