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Synthesis of sp(3)-rich heterocyclic frameworks by a divergent synthesis strategy
Fragment-based lead discovery (FBLD) often relies on flat, aromatic compounds which display undesirable physicochemical properties with limited exit vectors for fragment growth. Herein, we report concise synthetic strategies to sp(3)-rich heterocyclic fragments encompassing polar exit vectors poised...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246434/ https://www.ncbi.nlm.nih.gov/pubmed/37203457 http://dx.doi.org/10.1039/d3ob00351e |