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Predicting small molecule binding pockets on diacylglycerol kinases using chemoproteomics and AlphaFold
Diacylglycerol kinases (DGKs) are metabolic kinases involved in regulating cellular levels of diacylglycerol and phosphatidic lipid messengers. The development of selective inhibitors for individual DGKs would benefit from discovery of protein pockets available for inhibitor binding in cellular envi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
RSC
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246554/ https://www.ncbi.nlm.nih.gov/pubmed/37292058 http://dx.doi.org/10.1039/d3cb00057e |