Predicting small molecule binding pockets on diacylglycerol kinases using chemoproteomics and AlphaFold

Diacylglycerol kinases (DGKs) are metabolic kinases involved in regulating cellular levels of diacylglycerol and phosphatidic lipid messengers. The development of selective inhibitors for individual DGKs would benefit from discovery of protein pockets available for inhibitor binding in cellular envi...

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Detalles Bibliográficos
Autores principales: Mendez, Roberto, Shaikh, Minhaj, Lemke, Michael C., Yuan, Kun, Libby, Adam H., Bai, Dina L., Ross, Mark M., Harris, Thurl E., Hsu, Ku-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246554/
https://www.ncbi.nlm.nih.gov/pubmed/37292058
http://dx.doi.org/10.1039/d3cb00057e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246554/
https://www.ncbi.nlm.nih.gov/pubmed/37292058
http://dx.doi.org/10.1039/d3cb00057e

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