Selective BD2 Inhibitor Exerts Anti-Fibrotic Effects via BRD4/FoxM1/Plk1 Axis in Orbital Fibroblasts From Patients With Thyroid Eye Disease

PURPOSE: We investigated the therapeutic potential of ABBV744, a bromodomain and extra-terminal (BET) inhibitor with selectivity for the second bromodomain (BD2) in thyroid eye disease (TED). The anti-fibrotic effects of ABBV744 and its underlying mechanism were explored in cultured orbital fibrobla...

Descripción completa

Detalles Bibliográficos
Autores principales: Xie, Yanyan, Pan, Yuan, Chen, Qian, Chen, Yuxi, Chen, Guanyu, Wang, Mei, Zeng, Peng, Li, Zhuang, Li, Zuoyi, Wang, Sha, Yang, Huasheng, Liang, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Biochemistry and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246756/
https://www.ncbi.nlm.nih.gov/pubmed/37272763
http://dx.doi.org/10.1167/iovs.64.7.9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246756/
https://www.ncbi.nlm.nih.gov/pubmed/37272763
http://dx.doi.org/10.1167/iovs.64.7.9

Ejemplares similares