Cargando…

Selective BD2 Inhibitor Exerts Anti-Fibrotic Effects via BRD4/FoxM1/Plk1 Axis in Orbital Fibroblasts From Patients With Thyroid Eye Disease

PURPOSE: We investigated the therapeutic potential of ABBV744, a bromodomain and extra-terminal (BET) inhibitor with selectivity for the second bromodomain (BD2) in thyroid eye disease (TED). The anti-fibrotic effects of ABBV744 and its underlying mechanism were explored in cultured orbital fibrobla...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Yanyan, Pan, Yuan, Chen, Qian, Chen, Yuxi, Chen, Guanyu, Wang, Mei, Zeng, Peng, Li, Zhuang, Li, Zuoyi, Wang, Sha, Yang, Huasheng, Liang, Dan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2023
Materias:	Biochemistry and Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246756/ https://www.ncbi.nlm.nih.gov/pubmed/37272763 http://dx.doi.org/10.1167/iovs.64.7.9

Ejemplares similares

Plk1 Regulates the Repressor Function of FoxM1b by inhibiting its Interaction with the Retinoblastoma Protein
por: Mukhopadhyay, Nishit K., et al.
Publicado: (2017)

Author Correction: Plk1 Regulates the Repressor Function of FoxM1b by inhibiting its Interaction with the Retinoblastoma Protein
por: Mukhopadhyay, Nishit K., et al.
Publicado: (2018)

CDI Exerts Anti-Tumor Effects by Blocking the FoxM1-DNA Interaction
por: Jang, Woo Dae, et al.
Publicado: (2022)

High-risk histological subtype-related FAM83A hijacked FOXM1 transcriptional regulation to promote malignant progression in lung adenocarcinoma
por: Fei, Wei, et al.
Publicado: (2023)

The FOXM1-PLK1 axis is commonly upregulated in oesophageal adenocarcinoma
por: Dibb, M, et al.
Publicado: (2012)

FoxM1 is Upregulated in Osteosarcoma and Inhibition of FoxM1 Decreases Osteosarcoma Cell Proliferation, Migration, and Invasion
por: Zhu, Xia, et al.
Publicado: (2020)

Invasive FoxM1 phosphorylated by PLK1 induces the polarization of tumor-associated macrophages to promote immune escape and metastasis, amplified by IFITM1
por: Xu, Rong, et al.
Publicado: (2023)

Expression of FOXM1 and PLK1 predicts prognosis of patients with hepatocellular carcinoma
por: Fan, Weiqiang, et al.
Publicado: (2022)

Aberrantly high activation of a FoxM1–STMN1 axis contributes to progression and tumorigenesis in FoxM1-driven cancers
por: Liu, Jun, et al.
Publicado: (2021)

Overexpression of FoxM1 predicts poor prognosis of intrahepatic cholangiocarcinoma
por: Liu, Lingyun, et al.
Publicado: (2018)

FoxM1 knockdown enhanced radiosensitivity of esophageal cancer by inducing apoptosis
por: Qin, Qin, et al.
Publicado: (2023)

Identification and functional characterization of a β-glucosidase from Bacillus tequelensis BD69 expressed in bacterial and yeast heterologous systems
por: Raza, Ahmad, et al.
Publicado: (2020)

Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism
por: Lu, Huasong, et al.
Publicado: (2015)

FoxM1 Is a General Target for Proteasome Inhibitors
por: Bhat, Uppoor G., et al.
Publicado: (2009)

Deregulation of FoxM1b leads to tumour metastasis
por: Park, Hyun Jung, et al.
Publicado: (2011)

FoxM1 Induced Paclitaxel Resistance via Activation of the FoxM1/PHB1/RAF-MEK-ERK Pathway and Enhancement of the ABCA2 Transporter
por: Huang, Chao, et al.
Publicado: (2019)

FoxM1 is a promising candidate target in the treatment of breast cancer
por: Lu, Xiao-Feng, et al.
Publicado: (2017)

FoxM1 transactivates PTTG1 and promotes colorectal cancer cell migration and invasion
por: Zheng, Yun, et al.
Publicado: (2015)

Correction: Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism
por: Lu, Huasong, et al.
Publicado: (2015)

Broussoflavonol B from Broussonetia kazinoki Siebold Exerts Anti-Pancreatic Cancer Activity through Downregulating FoxM1
por: Jeong, Ji Hye, et al.
Publicado: (2020)

An order-to-disorder structural switch activates the FoxM1 transcription factor
por: Marceau, Aimee H, et al.
Publicado: (2019)

A Cdh1–FoxM1–Apc axis controls muscle development and regeneration
por: Chen, Zhe, et al.
Publicado: (2020)

Non-viral FoxM1 gene delivery to hepatocytes enhances liver repopulation
por: Xiang, D, et al.
Publicado: (2014)

Aberrant ASPM expression mediated by transcriptional regulation of FoxM1 promotes the progression of gliomas
por: Zeng, Wen‐Jing, et al.
Publicado: (2020)

Silencing of FoxM1 blocks growth, migration and invasion of papillary thyroid carcinoma cells
por: Wang, Xiaotao, et al.
Publicado: (2020)

Novel functions of FoxM1: from molecular mechanisms to cancer therapy
por: Alvarez-Fernández, Mónica, et al.
Publicado: (2013)

Effect of taxol on the expression of FoxM1 ovarian cancer-associated gene
por: LIU, ZENG, et al.
Publicado: (2016)

Participation of PLK1 and FOXM1 in the hyperplastic proliferation of pulmonary artery smooth muscle cells in pulmonary arterial hypertension
por: Wilson, Jamie L., et al.
Publicado: (2019)

ADAM-17 is a poor prognostic indicator for patients with hilar cholangiocarcinoma and is regulated by FoxM1
por: Jiao, Xiaodong, et al.
Publicado: (2018)

FoxM1 Promotes Glioma Cells Progression by Up-Regulating Anxa1 Expression
por: Cheng, Shi-Xiang, et al.
Publicado: (2013)

FoxM1 promotes epithelial-mesenchymal transition of hepatocellular carcinoma by targeting Snai1
por: Yu, Chun-Peng, et al.
Publicado: (2017)

Perfluorooctane sulfonate exerts inflammatory bowel disease-like intestinal injury in rats
por: Liang, Hai, et al.
Publicado: (2021)

Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation
por: Lin, Xiao-Tong, et al.
Publicado: (2021)

The tumor suppressive role of miRNA-370 by targeting FoxM1 in acute myeloid leukemia
por: Zhang, Xiaolu, et al.
Publicado: (2012)

Avasimibe inhibits tumor growth by targeting FoxM1-AKR1C1 in osteosarcoma
por: Wang, Liang, et al.
Publicado: (2019)

Avasimibe Dampens Cholangiocarcinoma Progression by Inhibiting FoxM1-AKR1C1 Signaling
por: Gao, Yunshu, et al.
Publicado: (2021)

Enzyme histochemical characterization of orbital glands in fetuses of Indian buffalo (Bubalus bubalis)
por: Tomar, Mahendra Pratap Singh, et al.
Publicado: (2023)

Thiazole Antibiotics Target FoxM1 and Induce Apoptosis in Human Cancer Cells
por: Bhat, Uppoor G., et al.
Publicado: (2009)

Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence
por: Littler, D. R., et al.
Publicado: (2010)

Expression of FoxM1 and the EMT-associated protein E-cadherin in gastric cancer and its clinical significance
por: Zhang, Jing, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_k17qomvaupor0avo3kp6nn8h2c