Hsp90 mutants with distinct defects provide novel insights into cochaperone regulation of the folding cycle

Molecular chaperones play a key role in maintaining proteostasis and cellular health. The abundant, essential, cytosolic Hsp90 (Heat shock protein, 90 kDa) facilitates the folding and activation of hundreds of newly synthesized or misfolded client proteins in an ATP-dependent folding pathway. In a s...

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Detalles Bibliográficos
Autores principales: Mercier, Rebecca, Yama, Danielle, LaPointe, Paul, Johnson, Jill L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246838/
https://www.ncbi.nlm.nih.gov/pubmed/37228112
http://dx.doi.org/10.1371/journal.pgen.1010772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246838/
https://www.ncbi.nlm.nih.gov/pubmed/37228112
http://dx.doi.org/10.1371/journal.pgen.1010772

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