Human SAMD9 is a poxvirus-activatable anticodon nuclease inhibiting codon-specific protein synthesis

As a defense strategy against viruses or competitors, some microbes use anticodon nucleases (ACNases) to deplete essential tRNAs, effectively halting global protein synthesis. However, this mechanism has not been observed in multicellular eukaryotes. Here, we report that human SAMD9 is an ACNase tha...

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Detalles Bibliográficos
Autores principales: Zhang, Fushun, Ji, Quanquan, Chaturvedi, Juhi, Morales, Marisol, Mao, Yuanhui, Meng, Xiangzhi, Dong, Leiming, Deng, Junpeng, Qian, Shu-Bing, Xiang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246899/
https://www.ncbi.nlm.nih.gov/pubmed/37285440
http://dx.doi.org/10.1126/sciadv.adh8502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246899/
https://www.ncbi.nlm.nih.gov/pubmed/37285440
http://dx.doi.org/10.1126/sciadv.adh8502

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