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Human SAMD9 is a poxvirus-activatable anticodon nuclease inhibiting codon-specific protein synthesis
As a defense strategy against viruses or competitors, some microbes use anticodon nucleases (ACNases) to deplete essential tRNAs, effectively halting global protein synthesis. However, this mechanism has not been observed in multicellular eukaryotes. Here, we report that human SAMD9 is an ACNase tha...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246899/ https://www.ncbi.nlm.nih.gov/pubmed/37285440 http://dx.doi.org/10.1126/sciadv.adh8502 |