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Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML314
The neurotensin receptor 1 (NTS(1)) is a G protein-coupled receptor (GPCR) with promise as a drug target for the treatment of pain, schizophrenia, obesity, addiction, and various cancers. A detailed picture of the NTS(1) structural landscape has been established by X-ray crystallography and cryo-EM...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247727/ https://www.ncbi.nlm.nih.gov/pubmed/37286565 http://dx.doi.org/10.1038/s41467-023-38894-8 |