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Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML314

The neurotensin receptor 1 (NTS(1)) is a G protein-coupled receptor (GPCR) with promise as a drug target for the treatment of pain, schizophrenia, obesity, addiction, and various cancers. A detailed picture of the NTS(1) structural landscape has been established by X-ray crystallography and cryo-EM...

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Detalles Bibliográficos
Autores principales:	Bumbak, Fabian, Bower, James B., Zemmer, Skylar C., Inoue, Asuka, Pons, Miquel, Paniagua, Juan Carlos, Yan, Fei, Ford, James, Wu, Hongwei, Robson, Scott A., Bathgate, Ross A. D., Scott, Daniel J., Gooley, Paul R., Ziarek, Joshua J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247727/ https://www.ncbi.nlm.nih.gov/pubmed/37286565 http://dx.doi.org/10.1038/s41467-023-38894-8

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