Integrated multi-omics analyses reveal homology-directed repair pathway as a unique dependency in near-haploid leukemia

Whole chromosome losses resulting in near-haploid karyotypes are found in a rare subgroup of treatment-refractory acute lymphoblastic leukemia. To systematically dissect the unique physiology and uncover susceptibilities that can be exploited in near-haploid leukemia, we leveraged single-cell RNA-Se...

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Detalles Bibliográficos
Autores principales: Liu-Lupo, Yunpeng, Ham, James Dongjoo, Jeewajee, Swarna K. A., Nguyen, Lan, Delorey, Toni, Ramos, Azucena, Weinstock, David M., Regev, Aviv, Hemann, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247733/
https://www.ncbi.nlm.nih.gov/pubmed/37286545
http://dx.doi.org/10.1038/s41408-023-00863-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247733/
https://www.ncbi.nlm.nih.gov/pubmed/37286545
http://dx.doi.org/10.1038/s41408-023-00863-1

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