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Integrated multi-omics analyses reveal homology-directed repair pathway as a unique dependency in near-haploid leukemia
Whole chromosome losses resulting in near-haploid karyotypes are found in a rare subgroup of treatment-refractory acute lymphoblastic leukemia. To systematically dissect the unique physiology and uncover susceptibilities that can be exploited in near-haploid leukemia, we leveraged single-cell RNA-Se...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247733/ https://www.ncbi.nlm.nih.gov/pubmed/37286545 http://dx.doi.org/10.1038/s41408-023-00863-1 |