Tox4 regulates transcriptional elongation and reinitiation during murine T cell development

HMG protein Tox4 is a regulator of PP1 phosphatases with unknown function in development. Here we show that Tox4 conditional knockout in mice reduces thymic cellularity, partially blocks T cell development, and decreases ratio of CD8 to CD4 through decreasing proliferation and increasing apoptosis o...

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Detalles Bibliográficos
Autores principales: Wang, Talang, Zhao, Ruoyu, Zhi, Junhong, Liu, Ziling, Wu, Aiwei, Yang, Zimei, Wang, Weixu, Ni, Ting, Jing, Lili, Yu, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247741/
https://www.ncbi.nlm.nih.gov/pubmed/37286708
http://dx.doi.org/10.1038/s42003-023-04992-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247741/
https://www.ncbi.nlm.nih.gov/pubmed/37286708
http://dx.doi.org/10.1038/s42003-023-04992-y

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