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Feeding the gut microbiome: impact on multiple sclerosis
Multiple sclerosis (MS) is a multifactorial neurological disease characterized by chronic inflammation and immune-driven demyelination of the central nervous system (CNS). The rising number of MS cases in the last decade could be partially attributed to environmental changes, among which the alterat...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248010/ https://www.ncbi.nlm.nih.gov/pubmed/37304278 http://dx.doi.org/10.3389/fimmu.2023.1176016 |
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author | Bronzini, Matteo Maglione, Alessandro Rosso, Rachele Matta, Manuela Masuzzo, Federica Rolla, Simona Clerico, Marinella |
author_facet | Bronzini, Matteo Maglione, Alessandro Rosso, Rachele Matta, Manuela Masuzzo, Federica Rolla, Simona Clerico, Marinella |
author_sort | Bronzini, Matteo |
collection | PubMed |
description | Multiple sclerosis (MS) is a multifactorial neurological disease characterized by chronic inflammation and immune-driven demyelination of the central nervous system (CNS). The rising number of MS cases in the last decade could be partially attributed to environmental changes, among which the alteration of the gut microbiome driven by novel dietary habits is now of particular interest. The intent of this review is to describe how diet can impact the development and course of MS by feeding the gut microbiome. We discuss the role of nutrition and the gut microbiota in MS disease, describing preclinical studies on experimental autoimmune encephalomyelitis (EAE) and clinical studies on dietary interventions in MS, with particular attention to gut metabolites–immune system interactions. Possible tools that target the gut microbiome in MS, such as the use of probiotics, prebiotics and postbiotics, are analyzed as well. Finally, we discuss the open questions and the prospects of these microbiome-targeted therapies for people with MS and for future research. |
format | Online Article Text |
id | pubmed-10248010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102480102023-06-09 Feeding the gut microbiome: impact on multiple sclerosis Bronzini, Matteo Maglione, Alessandro Rosso, Rachele Matta, Manuela Masuzzo, Federica Rolla, Simona Clerico, Marinella Front Immunol Immunology Multiple sclerosis (MS) is a multifactorial neurological disease characterized by chronic inflammation and immune-driven demyelination of the central nervous system (CNS). The rising number of MS cases in the last decade could be partially attributed to environmental changes, among which the alteration of the gut microbiome driven by novel dietary habits is now of particular interest. The intent of this review is to describe how diet can impact the development and course of MS by feeding the gut microbiome. We discuss the role of nutrition and the gut microbiota in MS disease, describing preclinical studies on experimental autoimmune encephalomyelitis (EAE) and clinical studies on dietary interventions in MS, with particular attention to gut metabolites–immune system interactions. Possible tools that target the gut microbiome in MS, such as the use of probiotics, prebiotics and postbiotics, are analyzed as well. Finally, we discuss the open questions and the prospects of these microbiome-targeted therapies for people with MS and for future research. Frontiers Media S.A. 2023-05-25 /pmc/articles/PMC10248010/ /pubmed/37304278 http://dx.doi.org/10.3389/fimmu.2023.1176016 Text en Copyright © 2023 Bronzini, Maglione, Rosso, Matta, Masuzzo, Rolla and Clerico https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Bronzini, Matteo Maglione, Alessandro Rosso, Rachele Matta, Manuela Masuzzo, Federica Rolla, Simona Clerico, Marinella Feeding the gut microbiome: impact on multiple sclerosis |
title | Feeding the gut microbiome: impact on multiple sclerosis |
title_full | Feeding the gut microbiome: impact on multiple sclerosis |
title_fullStr | Feeding the gut microbiome: impact on multiple sclerosis |
title_full_unstemmed | Feeding the gut microbiome: impact on multiple sclerosis |
title_short | Feeding the gut microbiome: impact on multiple sclerosis |
title_sort | feeding the gut microbiome: impact on multiple sclerosis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248010/ https://www.ncbi.nlm.nih.gov/pubmed/37304278 http://dx.doi.org/10.3389/fimmu.2023.1176016 |
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