Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation

Tauopathies are a group of neurodegenerative diseases, which include frontotemporal dementia (FTD) and Alzheimer’s disease (AD), broadly defined by the development of tau brain aggregates. Both missense and splicing tau mutations can directly cause early onset FTD. Tau protein is a microtubule-assoc...

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Detalles Bibliográficos
Autores principales: Xia, Yuxing, Bell, Brach M., Kim, Justin D., Giasson, Benoit I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248064/
https://www.ncbi.nlm.nih.gov/pubmed/37304025
http://dx.doi.org/10.3389/fnins.2023.1181804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248064/
https://www.ncbi.nlm.nih.gov/pubmed/37304025
http://dx.doi.org/10.3389/fnins.2023.1181804

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