Enhancer remodeling drives MLL oncogene-dependent transcriptional dysregulation in leukemia stem cells

Acute myeloid leukemia (AML) with mixed-lineage leukemia (MLL) gene rearrangement (MLLr) comprises a cellular hierarchy in which a subpopulation of cells serves as functional leukemia stem cells (LSCs). They are maintained by a unique gene expression program and chromatin states, which are thought t...

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Detalles Bibliográficos
Autores principales: Pan, Feng, Iwasaki, Masayuki, Wu, Wenqi, Jiang, Yanan, Yang, Xin, Zhu, Li, Zhao, Zhigang, Cleary, Michael L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248086/
https://www.ncbi.nlm.nih.gov/pubmed/36705973
http://dx.doi.org/10.1182/bloodadvances.2022008787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248086/
https://www.ncbi.nlm.nih.gov/pubmed/36705973
http://dx.doi.org/10.1182/bloodadvances.2022008787

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