Indolyl-chalcone derivatives trigger apoptosis in cisplatin-resistant mesothelioma cells through aberrant tubulin polymerization and deregulation of microtubule-associated proteins

INTRODUCTION: Malignant pleural mesothelioma (MPM) is a neoplasm with dismal prognosis and notorious resistance to the standard therapeutics cisplatin and pemetrexed. Chalcone derivatives are efficacious anti-cancer agents with minimal toxicity and have, therefore, gained pharmaceutical interest. He...

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Detalles Bibliográficos
Autores principales: Steinlein, Sophia, Essmann, Frank, Ghilardi, Amanda Franceschini, Horn, Heike, Schüler, Julia, Hausser, Angelika, Sun, Lijun, Ott, German, Kalla, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248254/
https://www.ncbi.nlm.nih.gov/pubmed/37305581
http://dx.doi.org/10.3389/fonc.2023.1190988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248254/
https://www.ncbi.nlm.nih.gov/pubmed/37305581
http://dx.doi.org/10.3389/fonc.2023.1190988

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