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Negative regulation of HBG1/2 expression through S6K by long noncoding RNA NR_120526

BACKGROUND: High levels of fetal hemoglobin (HbF) may alleviate clinical symptoms in patients with β-thalassemia. A previous study showed that the long noncoding RNA NR_120526 (lncRNA NR_120526) might be involved in regulating HbF levels (HBG1/2 gene expression). However, the function and mechanism...

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Detalles Bibliográficos
Autores principales: Jia, Wenguang, Wu, Xiaojing, Chen, Zhaohui, Lin, Weixiong, He, Yunyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248940/
https://www.ncbi.nlm.nih.gov/pubmed/37305725
http://dx.doi.org/10.21037/tp-23-174