Cargando…

AI-Assisted chemical probe discovery for the understudied Calcium-Calmodulin Dependent Kinase, PNCK

PNCK, or CAMK1b, is an understudied kinase of the calcium-calmodulin dependent kinase family which recently has been identified as a marker of cancer progression and survival in several large-scale multi-omics studies. The biology of PNCK and its relation to oncogenesis has also begun to be elucidat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Essegian, Derek J., Chavez, Valery, Khurshid, Rabia, Merchan, Jaime R., Schürer, Stephan C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249896/ https://www.ncbi.nlm.nih.gov/pubmed/37235579 http://dx.doi.org/10.1371/journal.pcbi.1010263

Ejemplares similares

Correction: AI-Assisted chemical probe discovery for the understudied Calcium-Calmodulin Dependent Kinase, PNCK
por: Essegian, Derek J., et al.
Publicado: (2023)

Cellular and molecular effects of PNCK, a non-canonical kinase target in renal cell carcinoma
por: Essegian, Derek J., et al.
Publicado: (2022)

The Clinical Kinase Index: A Method to Prioritize Understudied Kinases as Drug Targets for the Treatment of Cancer
por: Essegian, Derek, et al.
Publicado: (2020)

PNCK depletion inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells in vitro and in vivo
por: Xu, Yuanji, et al.
Publicado: (2019)

Pharos 2023: an integrated resource for the understudied human proteome
por: Kelleher, Keith J, et al.
Publicado: (2022)

Upregulation of PNCK Promotes Metastasis and Angiogenesis via Activating NF-κB/VEGF Pathway in Nasopharyngeal Carcinoma
por: Chen, Xiaochuan, et al.
Publicado: (2022)

Molecular Dynamics Simulations Identify Tractable Lead-like Phenyl-Piperazine Scaffolds as eIF4A1 ATP-competitive Inhibitors
por: Essegian, Derek J., et al.
Publicado: (2021)

Immune understudies combat lupus
por: Leslie, Mitch
Publicado: (2009)

Calcium and calmodulin function in the cell nucleus /
por: Bachs, Oriol
Publicado: (1995)

Spatiotemporal dynamics of calcium and calmodulin at the spine
por: Kalantzis, Georgios, et al.
Publicado: (2007)

Calcium-dependent binding of Myc to calmodulin
por: Raffeiner, Philipp, et al.
Publicado: (2016)

Calmodulin: The switch button of calcium signaling
por: Yang, Chiu-Fen, et al.
Publicado: (2021)

Careful with understudied phyla: The case of chaetognath
por: Marlétaz, Ferdinand, et al.
Publicado: (2008)

Editorial: Cardiometabolic diseases in understudied populations
por: Aguayo, Liliana, et al.
Publicado: (2023)

Calmodulin Contributes to Gating Control in Olfactory Calcium-activated Chloride Channels
por: Kaneko, Hiroshi, et al.
Publicado: (2006)

Pivoting between Calmodulin Lobes Triggered by Calcium in the Kv7.2/Calmodulin Complex
por: Alaimo, Alessandro, et al.
Publicado: (2014)

Genomics and evolutionary aspect of calcium signaling event in calmodulin and calmodulin-like proteins in plants
por: Mohanta, Tapan Kumar, et al.
Publicado: (2017)

Calcium Signalling in Heart and Vessels: Role of Calmodulin and Downstream Calmodulin-Dependent Protein Kinases
por: Beghi, Sofia, et al.
Publicado: (2022)

Discovery of 3-Amino-1H-pyrazole-Based Kinase Inhibitors to Illuminate the Understudied PCTAIRE Family
por: Amrhein, Jennifer Alisa, et al.
Publicado: (2022)

Role of calcium and calmodulin in hemidesmosome formation in vitro
Publicado: (1984)

The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin
por: Hou, Wenya, et al.
Publicado: (2015)

Acetylation stabilises calmodulin‐regulated calcium signalling
por: Baker, Karen, et al.
Publicado: (2022)

Assemblies of calcium/calmodulin-dependent kinase II with actin and their dynamic regulation by calmodulin in dendritic spines
por: Wang, Qian, et al.
Publicado: (2019)

Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels
por: Vocke, Kerstin, et al.
Publicado: (2013)

Genital Evolution: Why Are Females Still Understudied?
por: Ah-King, Malin, et al.
Publicado: (2014)

Percutaneous Coronary Intervention in Familial Hypercholesterolemia Is Understudied
por: Ungar, Leo, et al.
Publicado: (2018)

Editorial: Genomic Approaches for Improvement of Understudied Grasses
por: Amundsen, Keenan, et al.
Publicado: (2017)

Genetics of Inherited Retinal Diseases in Understudied Populations
por: Kannabiran, Chitra, et al.
Publicado: (2022)

Management of arrhythmias in underserved and understudied patient populations
por: Poole, Jeanne E.
Publicado: (2022)

Dietary protein and the intestinal microbiota: An understudied relationship
por: Bartlett, Alexandria, et al.
Publicado: (2022)

Erectile Dysfunction: Pharmacological Pathways with Understudied Potentials
por: Adam, Doaa R., et al.
Publicado: (2022)

Soil viruses: Understudied agents of soil ecology
por: Jansson, Janet K.
Publicado: (2022)

Cognitive decline assessment in speakers of understudied languages
por: Hatahet, Oula, et al.
Publicado: (2023)

Calmodulin confers calcium sensitivity on ciliary dynein ATPase
Publicado: (1980)

Myosin V: regulation by calcium, calmodulin, and the tail domain
por: Krementsov, Dimitry N., et al.
Publicado: (2004)

Participation of calcium and calmodulin in the formation of acetylcholine receptor clusters
Publicado: (1984)

Pathobiology of acute pancreatitis: focus on intracellular calcium and calmodulin
por: Petersen, Ole H., et al.
Publicado: (2011)

Calmodulin regulation (calmodulation) of voltage-gated calcium channels
por: Ben-Johny, Manu, et al.
Publicado: (2014)

Calcium/calmodulin-dependent kinase II and Alzheimer’s disease
por: Ghosh, Anshua, et al.
Publicado: (2015)

Regulation of mTORC1 by lysosomal calcium and calmodulin
por: Li, Ruo-Jing, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_s7am120ugbdspisdonf0afbm0o