Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides

Phosphorothioates (PS) have proven their effectiveness in the area of therapeutic oligonucleotides with applications spanning from cancer treatment to neurodegenerative disorders. Initially, PS substitution was introduced for the antisense oligonucleotides (PS ASOs) because it confers an increased n...

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Detalles Bibliográficos
Autores principales: Genna, Vito, Iglesias-Fernández, Javier, Reyes-Fraile, Laura, Villegas, Nuria, Guckian, Kevin, Seth, Punit, Wan, Brad, Cabrero, Cristina, Terrazas, Montserrat, Brun-Heath, Isabelle, González, Carlos, Sciabola, Simone, Villalobos, Anabella, Orozco, Modesto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250214/
https://www.ncbi.nlm.nih.gov/pubmed/37099382
http://dx.doi.org/10.1093/nar/gkad309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250214/
https://www.ncbi.nlm.nih.gov/pubmed/37099382
http://dx.doi.org/10.1093/nar/gkad309

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