Oocytes can repair DNA damage during meiosis via a microtubule-dependent recruitment of CIP2A–MDC1–TOPBP1 complex from spindle pole to chromosomes

Because DNA double-strand breaks (DSBs) greatly threaten genomic integrity, effective DNA damage sensing and repair are essential for cellular survival in all organisms. However, DSB repair mainly occurs during interphase and is repressed during mitosis. Here, we show that, unlike mitotic cells, ooc...

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Detalles Bibliográficos
Autores principales: Leem, Jiyeon, Kim, Jae-Sung, Oh, Jeong Su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250218/
https://www.ncbi.nlm.nih.gov/pubmed/36999590
http://dx.doi.org/10.1093/nar/gkad213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250218/
https://www.ncbi.nlm.nih.gov/pubmed/36999590
http://dx.doi.org/10.1093/nar/gkad213

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