Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). The NSP15 endoribonuclease enzyme, known as NendoU, is highly conserved and plays a critical role in the ability of the virus to evade the immune system. NendoU is a promising...

Descripción completa

Detalles Bibliográficos
Autores principales: Godoy, Andre Schutzer, Nakamura, Aline Minalli, Douangamath, Alice, Song, Yun, Noske, Gabriela Dias, Gawriljuk, Victor Oliveira, Fernandes, Rafaela Sachetto, Pereira, Humberto D Muniz, Oliveira, Ketllyn Irene Zagato, Fearon, Daren, Dias, Alexandre, Krojer, Tobias, Fairhead, Michael, Powell, Alisa, Dunnet, Louise, Brandao-Neto, Jose, Skyner, Rachael, Chalk, Rod, Bajusz, Dávid, Bege, Miklós, Borbás, Anikó, Keserű, György Miklós, von Delft, Frank, Oliva, Glaucius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250223/
https://www.ncbi.nlm.nih.gov/pubmed/37115000
http://dx.doi.org/10.1093/nar/gkad314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250223/
https://www.ncbi.nlm.nih.gov/pubmed/37115000
http://dx.doi.org/10.1093/nar/gkad314

Ejemplares similares