Negatively charged, intrinsically disordered regions can accelerate target search by DNA-binding proteins

In eukaryotes, many DNA/RNA-binding proteins possess intrinsically disordered regions (IDRs) with large negative charge, some of which involve a consecutive sequence of aspartate (D) or glutamate (E) residues. We refer to them as D/E repeats. The functional role of D/E repeats is not well understood...

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Detalles Bibliográficos
Autores principales: Wang, Xi, Bigman, Lavi S, Greenblatt, Harry M, Yu, Binhan, Levy, Yaakov, Iwahara, Junji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250230/
https://www.ncbi.nlm.nih.gov/pubmed/36774964
http://dx.doi.org/10.1093/nar/gkad045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250230/
https://www.ncbi.nlm.nih.gov/pubmed/36774964
http://dx.doi.org/10.1093/nar/gkad045

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