Phase-separated DropCRISPRa platform for efficient gene activation in mammalian cells and mice

Liquid–liquid phase separation (LLPS) plays a critical role in regulating gene transcription via the formation of transcriptional condensates. However, LLPS has not been reported to be engineered as a tool to activate endogenous gene expression in mammalian cells or in vivo. Here, we developed a dro...

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Detalles Bibliográficos
Autores principales: Ma, Shufeng, Liao, Kaitong, Li, Mengrao, Wang, Xinlong, Lv, Jie, Zhang, Xin, Huang, Hongxin, Li, Lian, Huang, Tao, Guo, Xiaohua, Lin, Ying, Rong, Zhili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250237/
https://www.ncbi.nlm.nih.gov/pubmed/37094074
http://dx.doi.org/10.1093/nar/gkad301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250237/
https://www.ncbi.nlm.nih.gov/pubmed/37094074
http://dx.doi.org/10.1093/nar/gkad301

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