TRIM5α recruits HDAC1 to p50 and Sp1 and promotes H3K9 deacetylation at the HIV-1 LTR

Tripartite motif-containing protein 5α (TRIM5α) is generally known to block the postentry events of HIV-1. Here, we report an uncharacterized role for TRIM5α in the maintenance of viral latency. Knockdown of TRIM5α potentiates the transcription of HIV-1 in multiple latency models, which is reversed...

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Detalles Bibliográficos
Autores principales: Ran, Xiang-Hong, Zhu, Jia-Wu, Ni, Run-Ze, Zheng, Yong-Tang, Chen, Ya-Yun, Zheng, Wei-Hua, Mu, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250300/
https://www.ncbi.nlm.nih.gov/pubmed/37291137
http://dx.doi.org/10.1038/s41467-023-39056-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250300/
https://www.ncbi.nlm.nih.gov/pubmed/37291137
http://dx.doi.org/10.1038/s41467-023-39056-6

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