Template-jumping prime editing enables large insertion and exon rewriting in vivo

Targeted insertion of large DNA fragments holds promise for genome engineering and gene therapy. Prime editing (PE) effectively inserts short (<50 bp) sequences. Employing paired prime editing guide RNAs (pegRNAs) has enabled PE to better mediate relatively large insertions in vitro, but the effi...

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Detalles Bibliográficos
Autores principales: Zheng, Chunwei, Liu, Bin, Dong, Xiaolong, Gaston, Nicholas, Sontheimer, Erik J., Xue, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250319/
https://www.ncbi.nlm.nih.gov/pubmed/37291100
http://dx.doi.org/10.1038/s41467-023-39137-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250319/
https://www.ncbi.nlm.nih.gov/pubmed/37291100
http://dx.doi.org/10.1038/s41467-023-39137-6

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