Transcriptional control of pancreatic cancer immunosuppression by metabolic enzyme CD73 in a tumor-autonomous and -autocrine manner

Cancer cell metabolism contributes to the establishment of an immunosuppressive tumor microenvironment. Aberrant expression of CD73, a critical enzyme in ATP metabolism, on the cell surface results in the extracellular accumulation of adenosine, which exhibits direct inhibitory effects on tumor-infi...

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Detalles Bibliográficos
Autores principales: Tang, Tianyu, Huang, Xing, Lu, Minghao, Zhang, Gang, Han, Xu, Liang, Tingbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250326/
https://www.ncbi.nlm.nih.gov/pubmed/37291128
http://dx.doi.org/10.1038/s41467-023-38578-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250326/
https://www.ncbi.nlm.nih.gov/pubmed/37291128
http://dx.doi.org/10.1038/s41467-023-38578-3

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