Generating immunogenomic data-guided virtual patients using a QSP model to predict response of advanced NSCLC to PD-L1 inhibition

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Generating realistic virtual patients from a limited amount of patient data is one of the major challenges for quantitative systems pharmacology modeling in immuno-oncology. Quantitative systems pharmacology (QSP) is a mathematical modeling methodology that integrates mechanistic knowledge of biolog...

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Detalles Bibliográficos
Autores principales: Wang, Hanwen, Arulraj, Theinmozhi, Kimko, Holly, Popel, Aleksander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250344/
https://www.ncbi.nlm.nih.gov/pubmed/37291190
http://dx.doi.org/10.1038/s41698-023-00405-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250344/
https://www.ncbi.nlm.nih.gov/pubmed/37291190
http://dx.doi.org/10.1038/s41698-023-00405-9

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