PPARδ inhibition blocks the induction and function of tumor-induced IL-10(+) regulatory B cells and enhances cancer immunotherapy

IL-10(+) regulatory B cells (Bregs) play a significant role in cancer immunotherapy and their presence is an indicator of negative outcome. We found that PPARδ is significantly upregulated in tumor-induced IL-10(+) Bregs with a phenotype of CD19(+)CD24(hi)IgD(lo/−)CD38(lo) or CD19(+)CD24(hi)IgD(lo/−...

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Detalles Bibliográficos
Autores principales: Chen, Chen, Ma, Jianan, Pi, Chenchen, Huang, Wei, Zhang, Tao, Fu, Cong, Liu, Wentao, Yang, Yong-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250529/
https://www.ncbi.nlm.nih.gov/pubmed/37291146
http://dx.doi.org/10.1038/s41421-023-00568-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250529/
https://www.ncbi.nlm.nih.gov/pubmed/37291146
http://dx.doi.org/10.1038/s41421-023-00568-6

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