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PPARδ inhibition blocks the induction and function of tumor-induced IL-10(+) regulatory B cells and enhances cancer immunotherapy
IL-10(+) regulatory B cells (Bregs) play a significant role in cancer immunotherapy and their presence is an indicator of negative outcome. We found that PPARδ is significantly upregulated in tumor-induced IL-10(+) Bregs with a phenotype of CD19(+)CD24(hi)IgD(lo/−)CD38(lo) or CD19(+)CD24(hi)IgD(lo/−...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Nature Singapore
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250529/ https://www.ncbi.nlm.nih.gov/pubmed/37291146 http://dx.doi.org/10.1038/s41421-023-00568-6 |