Cellular uptake of modified mRNA occurs via caveolae-mediated endocytosis, yielding high protein expression in slow-dividing cells

Nucleic acids have clear clinical potential for gene therapy. Plasmid DNA (pDNA) was the first nucleic acid to be pursued as a therapeutic molecule. Recently, mRNA came into play as it offers improved safety and affordability. In this study, we investigated the uptake mechanisms and efficiencies of...

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Detalles Bibliográficos
Autores principales: Del Toro Runzer, Claudia, Anand, Shivesh, Mota, Carlos, Moroni, Lorenzo, Plank, Christian, van Griensven, Martijn, Balmayor, Elizabeth R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250585/
https://www.ncbi.nlm.nih.gov/pubmed/37305166
http://dx.doi.org/10.1016/j.omtn.2023.05.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250585/
https://www.ncbi.nlm.nih.gov/pubmed/37305166
http://dx.doi.org/10.1016/j.omtn.2023.05.019

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