Spirocyclopiperazinium salt compound DXL-A-24 improves visceral sensation and gut microbiota in a rat model of irritable bowel syndrome

Irritable bowel syndrome (IBS) is characterized by visceral pain, impaired intestinal barrier and a disorder of the microbiota. DXL-A-24 has analgesic and anti-inflammatory effects by inhibiting neuropeptides and inflammatory factors. In this study, we used chronic unpredictable mild stress (CUMS) i...

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Detalles Bibliográficos
Autores principales: Xu, Yan, Yao, Ru, Zhao, Wenxue, Zhu, Jianguo, Yao, Jingchun, Zhang, Guimin, Liu, Dongguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250758/
https://www.ncbi.nlm.nih.gov/pubmed/37303540
http://dx.doi.org/10.1016/j.heliyon.2023.e16544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250758/
https://www.ncbi.nlm.nih.gov/pubmed/37303540
http://dx.doi.org/10.1016/j.heliyon.2023.e16544

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