Cargando…

Spirocyclopiperazinium salt compound DXL-A-24 improves visceral sensation and gut microbiota in a rat model of irritable bowel syndrome

Irritable bowel syndrome (IBS) is characterized by visceral pain, impaired intestinal barrier and a disorder of the microbiota. DXL-A-24 has analgesic and anti-inflammatory effects by inhibiting neuropeptides and inflammatory factors. In this study, we used chronic unpredictable mild stress (CUMS) i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Yan, Yao, Ru, Zhao, Wenxue, Zhu, Jianguo, Yao, Jingchun, Zhang, Guimin, Liu, Dongguang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250758/ https://www.ncbi.nlm.nih.gov/pubmed/37303540 http://dx.doi.org/10.1016/j.heliyon.2023.e16544

Ejemplares similares

Mast cell mediation of visceral sensation and permeability in irritable bowel syndrome
por: Hasler, William L., et al.
Publicado: (2022)

Stress-Related Alterations of Visceral Sensation: Animal Models for Irritable Bowel Syndrome Study
por: Larauche, Muriel, et al.
Publicado: (2011)

A Choreography-Driven Approach to APIs: The OpenDXL Case Study
por: Frittelli, Leonardo, et al.
Publicado: (2020)

A Pilot Study of the Effect of Daikenchuto on Rectal Sensation in Patients with Irritable Bowel Syndrome
por: Acosta, Andres, et al.
Publicado: (2016)

Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases
por: Ceuleers, Hannah, et al.
Publicado: (2016)

Salt Sensation and Regulation
por: Puri, Sonali, et al.
Publicado: (2021)

Research Progress in Fecal Microbiota Transplantation as Treatment for Irritable Bowel Syndrome
por: Wang, Yao, et al.
Publicado: (2019)

A brainstem map for visceral sensations
por: Ran, Chen, et al.
Publicado: (2022)

Bifidobacterium longum alleviates irritable bowel syndrome-related visceral hypersensitivity and microbiota dysbiosis via Paneth cell regulation
por: Zhou, Chunhua, et al.
Publicado: (2020)

Gut microbiota was modulated by moxibustion stimulation in rats with irritable bowel syndrome
por: Wang, Xiaomei, et al.
Publicado: (2018)

Anti-Inflammation of Spirocyclopiperazinium Salt Compound LXM-10 Targeting α7 nAChR and M4 mAChR and Inhibiting JAK2/STAT3 Pathway in Rats
por: Zhang, Weiwei, et al.
Publicado: (2013)

Irritable Bowel Syndrome, Gut Microbiota and Probiotics
por: Lee, Beom Jae, et al.
Publicado: (2011)

Gut Microbiota Manipulation in Irritable Bowel Syndrome
por: Mazzawi, Tarek
Publicado: (2022)

Fecal microbiota profiling in irritable bowel syndrome and inflammatory bowel disease patients with irritable bowel syndrome-type symptoms
por: Cui, Xiufang, et al.
Publicado: (2021)

Irritable bowel syndrome: Is it “irritable brain” or “irritable bowel”?
por: Padhy, Susanta Kumar, et al.
Publicado: (2015)

Safety evaluation of the food enzyme endo‐1,4‐β‐xylanase and β‐glucanase from Disporotrichum dimorphosporum strain DXL
por: Silano, Vittorio, et al.
Publicado: (2020)

Main ion channels and receptors associated with visceral hypersensitivity in irritable bowel syndrome
por: de Carvalho Rocha, Heraldo Arcela, et al.
Publicado: (2014)

New Pathways, New Targets: Visceral Hypersensitivity Pathogenesis in Irritable Bowel Syndrome
por: Barshop, Kenneth, et al.
Publicado: (2016)

Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome
por: Asano, Teita, et al.
Publicado: (2017)

The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments
por: Farzaei, Mohammad H, et al.
Publicado: (2016)

Piezo2: A Candidate Biomarker for Visceral Hypersensitivity in Irritable Bowel Syndrome?
por: Bai, Tao, et al.
Publicado: (2017)

Brain functional connectivity is associated with visceral sensitivity in women with Irritable Bowel Syndrome
por: Icenhour, Adriane, et al.
Publicado: (2017)

The Importance of Visceral Hypersensitivity in Irritable Bowel Syndrome—Plant Metabolites in IBS Treatment
por: Dudzińska, Ewa, et al.
Publicado: (2023)

Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome
por: Zhang, Yu, et al.
Publicado: (2019)

The Gut Microbiota and Irritable Bowel Syndrome: Friend or Foe?
por: Ghoshal, Uday C., et al.
Publicado: (2012)

Gut Microbiota as Potential Orchestrators of Irritable Bowel Syndrome
por: Bennet, Sean M.P., et al.
Publicado: (2015)

Gut Microbiota-Based Therapies for Irritable Bowel Syndrome
por: Stern, Emily K, et al.
Publicado: (2018)

Gut Microbiota-Derived Metabolites in Irritable Bowel Syndrome
por: Xiao, Lin, et al.
Publicado: (2021)

Bile Acid and Gut Microbiota in Irritable Bowel Syndrome
por: Min, Yang Won, et al.
Publicado: (2022)

Gut microbiota signatures and modulation in irritable bowel syndrome
por: Marasco, Giovanni, et al.
Publicado: (2022)

Publisher Correction: A brainstem map for visceral sensations
por: Ran, Chen, et al.
Publicado: (2022)

Laser-Supported Dual Energy X-Ray Absorptiometry (DXL) Compared to Conventional Absorptiometry (DXA) and to FRAX as Tools for Fracture Risk Assessments
por: Lundin, Hans, et al.
Publicado: (2015)

The Effect of Allogenic Versus Autologous Fecal Microbiota Transfer on Symptoms, Visceral Perception and Fecal and Mucosal Microbiota in Irritable Bowel Syndrome: A Randomized Controlled Study
por: Holster, Savanne, et al.
Publicado: (2019)

The severity of irritable bowel syndrome or the presence of fibromyalgia influencing the perception of visceral and somatic stimuli
por: Tremolaterra, Fabrizio, et al.
Publicado: (2014)

Butyrate inhibits visceral allodynia and colonic hyperpermeability in rat models of irritable bowel syndrome
por: Nozu, Tsukasa, et al.
Publicado: (2019)

Global research progress of visceral hypersensitivity and irritable bowel syndrome: bibliometrics and visualized analysis
por: Tian, Siyu, et al.
Publicado: (2023)

The efficacy and neural mechanism of acupuncture therapy in the treatment of visceral hypersensitivity in irritable bowel syndrome
por: Yang, Yuanzhen, et al.
Publicado: (2023)

Translation and validation of the Ukrainian version of the visceral sensitivity index for patients with irritable bowel syndrome
por: Neverovskyi, Artem, et al.
Publicado: (2023)

Fecal and Mucosal Microbiota Profiling in Irritable Bowel Syndrome and Inflammatory Bowel Disease
por: Lo Presti, Alessandra, et al.
Publicado: (2019)

Altered profiles of fecal metabolites correlate with visceral hypersensitivity and may contribute to symptom severity of diarrhea-predominant irritable bowel syndrome
por: Zhang, Wen-Xue, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_9k5u1gso04kf0cqc56fe5re3k6