Aromatic oligoesters as novel helix mimetic scaffolds

The design, synthesis, and conformational analysis of a novel aromatic oligoester helix mimetic scaffold is reported. A range of amino acid-type side-chain functionality can be readily incorporated into monomer building blocks over three facile synthetic steps. Analysis of representative dimers reve...

Descripción completa

Detalles Bibliográficos
Autores principales: Haque, Muhammed, Flack, Theo, Singh, Ravi, Wall, Archie, de Castro, Guilherme Vieira, Jiang, Lishen, White, Andrew J.P., Barnard, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250785/
https://www.ncbi.nlm.nih.gov/pubmed/37182518
http://dx.doi.org/10.1016/j.bmc.2023.117311
Descripción
Sumario:The design, synthesis, and conformational analysis of a novel aromatic oligoester helix mimetic scaffold is reported. A range of amino acid-type side-chain functionality can be readily incorporated into monomer building blocks over three facile synthetic steps. Analysis of representative dimers revealed a stable conformer capable of effective mimicry of a canonical α-helix and the scaffold was found to be surprisingly stable to degradation in aqueous solutions at acidic and neutral pH.

Ejemplares similares