A novel fluorogenic reporter substrate for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCγ2): Application to high-throughput screening for activators to treat Alzheimer’s disease

A rare coding variant in PLCγ2 (P522R) expressed in microglia induces a mild activation of enzymatic activity when compared to wild-type. This mutation is reported to be protective against the cognitive decline associated with late-onset Alzheimer’s disease (LOAD) and therefore, activation of wild-t...

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Detalles Bibliográficos
Autores principales: Visvanathan, Ramya, Utsuki, Tadanobu, Beck, Daniel E., Lendy, Emma, Sun, Kuai-lin, Liu, Yinghui, Hering, Kirk W., Mesecar, Andrew, Zhang, Zhong-Yin, Putt, Karson S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251139/
https://www.ncbi.nlm.nih.gov/pubmed/36933698
http://dx.doi.org/10.1016/j.slasd.2023.03.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251139/
https://www.ncbi.nlm.nih.gov/pubmed/36933698
http://dx.doi.org/10.1016/j.slasd.2023.03.003

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