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IL-15-producing splenic B cells play pathogenic roles in the development of autoimmune hepatitis
BACKGROUND & AIMS: B-cell depletion therapy with an anti-CD20 is an effective treatment strategy for patients with refractory autoimmune hepatitis (AIH). However, the mechanisms underlying B-cell action are unclear. METHODS: Herein, we used the adeno-associated virus IL-12 model, in which hepati...
Main Authors: | , , , , , , , , , , , , , , , , , , , |
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Format: | Online Article Text |
Language: | English |
Published: |
Elsevier
2023
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Subjects: | |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251155/ https://www.ncbi.nlm.nih.gov/pubmed/37305442 http://dx.doi.org/10.1016/j.jhepr.2023.100757 |