IL-15-producing splenic B cells play pathogenic roles in the development of autoimmune hepatitis

BACKGROUND & AIMS: B-cell depletion therapy with an anti-CD20 is an effective treatment strategy for patients with refractory autoimmune hepatitis (AIH). However, the mechanisms underlying B-cell action are unclear. METHODS: Herein, we used the adeno-associated virus IL-12 model, in which hepati...

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Detalles Bibliográficos
Autores principales: Fujimori, Sota, Chu, Po-Sung, Teratani, Toshiaki, Harada, Yosuke, Suzuki, Takahiro, Amiya, Takeru, Taniki, Nobuhito, Kasuga, Ryosuke, Mikami, Yohei, Koda, Yuzo, Ichikawa, Masataka, Tabuchi, Takaya, Morikawa, Rei, Yamataka, Karin, Noguchi, Fumie, Tsujikawa, Hanako, Kurebayashi, Yutaka, Sakamoto, Michiie, Kanai, Takanori, Nakamoto, Nobuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251155/
https://www.ncbi.nlm.nih.gov/pubmed/37305442
http://dx.doi.org/10.1016/j.jhepr.2023.100757

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