Doubly Constrained C-terminal of Roc (COR) Domain-Derived Peptides Inhibit Leucine-Rich Repeat Kinase 2 (LRRK2) Dimerization

[Image: see text] Missense mutations along the leucine-rich repeat kinase 2 (LRRK2) protein are a major contributor to Parkinson’s Disease (PD), the second most commonly occurring neurodegenerative disorder worldwide. We recently reported the development of allosteric constrained peptide inhibitors...

Descripción completa

Detalles Bibliográficos
Autores principales: Pathak, Pragya, Alexander, Krista K., Helton, Leah G., Kentros, Michalis, LeClair, Timothy J., Zhang, Xiaojuan, Ho, Franz Y., Moore, Timothy T., Hall, Scotty, Guaitoli, Giambattista, Gloeckner, Christian Johannes, Kortholt, Arjan, Rideout, Hardy, Kennedy, Eileen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251477/
https://www.ncbi.nlm.nih.gov/pubmed/37200505
http://dx.doi.org/10.1021/acschemneuro.3c00259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251477/
https://www.ncbi.nlm.nih.gov/pubmed/37200505
http://dx.doi.org/10.1021/acschemneuro.3c00259

Ejemplares similares