PROTAC-Induced Glycogen Synthase Kinase 3β Degradation as a Potential Therapeutic Strategy for Alzheimer’s Disease

[Image: see text] Glycogen synthase kinase 3β (GSK-3β) is a serine/threonine kinase and an attractive therapeutic target for Alzheimer’s disease. Based on proteolysis-targeting chimera (PROTAC) technology, a small set of novel GSK-3β degraders was designed and synthesized by linking two different GS...

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Detalles Bibliográficos
Autores principales: Guardigni, Melissa, Pruccoli, Letizia, Santini, Alan, Simone, Angela De, Bersani, Matteo, Spyrakis, Francesca, Frabetti, Flavia, Uliassi, Elisa, Andrisano, Vincenza, Pagliarani, Barbara, Fernández-Gómez, Paula, Palomo, Valle, Bolognesi, Maria Laura, Tarozzi, Andrea, Milelli, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251479/
https://www.ncbi.nlm.nih.gov/pubmed/37218653
http://dx.doi.org/10.1021/acschemneuro.3c00096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251479/
https://www.ncbi.nlm.nih.gov/pubmed/37218653
http://dx.doi.org/10.1021/acschemneuro.3c00096

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