Cooperativity boosts affinity and specificity of proteins with multiple RNA-binding domains

Numerous cellular processes rely on the binding of proteins with high affinity to specific sets of RNAs. Yet most RNA-binding domains display low specificity and affinity in comparison to DNA-binding domains. The best binding motif is typically only enriched by less than a factor 10 in high-throughp...

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Detalles Bibliográficos
Autores principales: Stitzinger, Simon H, Sohrabi-Jahromi, Salma, Söding, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Standard Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251633/
https://www.ncbi.nlm.nih.gov/pubmed/37305168
http://dx.doi.org/10.1093/nargab/lqad057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251633/
https://www.ncbi.nlm.nih.gov/pubmed/37305168
http://dx.doi.org/10.1093/nargab/lqad057

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