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Cooperativity boosts affinity and specificity of proteins with multiple RNA-binding domains
Numerous cellular processes rely on the binding of proteins with high affinity to specific sets of RNAs. Yet most RNA-binding domains display low specificity and affinity in comparison to DNA-binding domains. The best binding motif is typically only enriched by less than a factor 10 in high-throughp...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251633/ https://www.ncbi.nlm.nih.gov/pubmed/37305168 http://dx.doi.org/10.1093/nargab/lqad057 |