TP53 germline pathogenic variants in modern humans were likely originated during recent human history

TP53 is crucial for maintaining genome stability and preventing oncogenesis. Germline pathogenic variation in TP53 damages its function, causing genome instability and increased cancer risk. Despite extensive study in TP53, the evolutionary origin of the human TP53 germline pathogenic variants remai...

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Detalles Bibliográficos
Autores principales: Kou, Si Hoi, Li, Jiaheng, Tam, Benjamin, Lei, Huijun, Zhao, Bojin, Xiao, Fengxia, Wang, San Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Cancer Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251638/
https://www.ncbi.nlm.nih.gov/pubmed/37304756
http://dx.doi.org/10.1093/narcan/zcad025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251638/
https://www.ncbi.nlm.nih.gov/pubmed/37304756
http://dx.doi.org/10.1093/narcan/zcad025

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