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Metformin ameliorates ferroptosis in cardiac ischemia and reperfusion by reducing NOX4 expression via promoting AMPKα
CONTEXT: Metformin (Met) has a protective effect against cardiac ischemia and reperfusion (I/R) injury. OBJECTIVE: This study uncovered the Met effect on ferroptosis in cardiac I/R. MATERIALS AND METHODS: Sprague-Dawley rats underwent cardiac I/R treatment (ischaemia 30 min; reperfusion 24 h) (I/R g...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251788/ https://www.ncbi.nlm.nih.gov/pubmed/37288723 http://dx.doi.org/10.1080/13880209.2023.2212700 |