Metformin ameliorates ferroptosis in cardiac ischemia and reperfusion by reducing NOX4 expression via promoting AMPKα

CONTEXT: Metformin (Met) has a protective effect against cardiac ischemia and reperfusion (I/R) injury. OBJECTIVE: This study uncovered the Met effect on ferroptosis in cardiac I/R. MATERIALS AND METHODS: Sprague-Dawley rats underwent cardiac I/R treatment (ischaemia 30 min; reperfusion 24 h) (I/R g...

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Detalles Bibliográficos
Autores principales: Wu, Zhenhua, Bai, Yunpeng, Qi, Yujuan, Chang, Chao, Jiao, Yan, Bai, Yaobang, Guo, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251788/
https://www.ncbi.nlm.nih.gov/pubmed/37288723
http://dx.doi.org/10.1080/13880209.2023.2212700

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